B cells spread to affinity
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چکیده
منابع مشابه
B cells spread to affinity
B cells spread to affinity B cells extend like fi shnets to capture and then draw in antigens, according to new research and colleagues. The mechanism allows B cells to discern the affi nities of the different membrane-bound antigens they encounter. The interaction of B cell receptors with antigens gives birth to the immunological synapse, spurring B cell activation and antigen presentation to ...
متن کاملFacundo Batista: watching B cells spread and grab antigens
Early in an immune response, B cells latch on to antigens embedded in the surface membranes of follicular den-dritic cells and macrophages. Engagement with antigen spurs a flurry of activity at the point of contact on the B cell surface—a phenomenon that Facundo Batista is documenting in molecular detail. During his post-doctoral research, Batista discovered that B cell receptors (BCRs) must ex...
متن کاملLocal BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation
We have assessed the role of B lymphocyte stimulator (BLyS) and its receptors in the germinal center (GC) reaction and affinity maturation. Despite ample BLyS retention on B cells in follicular (FO) regions, the GC microenvironment lacks substantial BLyS. This reflects IL-21-mediated down-regulation of the BLyS receptor TACI (transmembrane activator and calcium modulator and cyclophilin ligand ...
متن کاملAntigen drives very low affinity B cells to become plasmacytes and enter germinal centers.
In the first week of the primary immune response to the (4-hydroxy-3-nitrophenyl)acetyl (NP) hapten, plasmacytic foci and germinal centers (GCs) in C57BL/6 mice are comprised of polyclonal populations of B lymphocytes bearing the lambda1 L-chain (lambda1+). The Ig H-chains of these early populations of B cells are encoded by a variety of VH and D exons undiversified by hypermutation while later...
متن کاملAffinity Discrimination in B cells in Response to Membrane Antigen Requires Kinetic Proofreading
B cells signaling in response to antigen is proportional to antigen affinity, a process known as affinity discrimination. Recent research suggests that B cells can acquire antigen in membranebound form on the surface of antigen-presenting cells (APCs), with signaling being initiated within a few seconds of B cell/APC contact. During the earliest stages of B cell/APC contact, B cell receptors (B...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2006
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1735rr1